The Key Role Of Stem Cells In Lethal Gastric Cancer Revealed
In a recent study published in Nature Communications, scientists from Cornell University made new findings in common and fatal gastric cancer research. In the United States, the incidence of gastroesophageal cancer increased 2.5-fold from the 1970s to the early 2000s, however, from the 1950s, the number of all patients with gastric cancer decreased by more than 80%; despite this, gastric cancer is still the fifth most common cancer and the third leading cause of cancer death worldwide.
In this study, the researchers identified a novel pathway in gastroesophageal cancer that may be expected to serve as a potential target to help develop novel therapies; a type of stem cell offspring called Lgr5 + may gather in large numbers, thereby promoting the development of cancer at the encounter between the two gastric tissues. Professor Alexander Nikitin, a researcher, said that at the global level, gastric squamous columnar junction cancer (gastroesophageal cancer) is a frequent disease and the prognosis of patients is poor, so it is essential to study the mechanism of this type of cancer formation and how it is treated.
In this study, the researchers developed experimental mouse models carrying two tumor suppressor genes that can become inactivated under specific conditions, a model that meets a number of parameters necessary to perform accurate studies of cancer, and previous researchers have certain limitations in mouse studies, that is, mice golden glow produce specific types of tumors or premature death, which undoubtedly inhibits the conduct of the study, but in this study, the mouse model developed by the researchers was able to develop a related form of metastatic gastric columnar junction cancer.
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