R&D Platform
ERA™ and iPSC represent two ends of the cellular reprogramming continuum. Both technologies use carefully formulated mRNA cocktails of transcription factors – specific proteins like Myc, Oct3/4, Sox2 and Klf4 – that turn a gene on or off by controlling the rate of transcription of genetic information from DNA to messenger RNA. This information controls the cell’s function.
With ERA™, a cell’s exposure to both the dosing and timing of transcription factors is carefully controlled and more limited than with iPSC. The goal is to maintain cellular identity, but restore cell effectiveness by “turning back the clock” on the epigenome, which regulates how a cell functions and records cellular age.
